استراجاليس:
معجزة الطبيعه
لاحظ تأثيرات استراجاليس من خلال الرسم التوضيحى المرفق
عرف الإنسان نبات استراجاليس من قديم الزمن فى الصين وهو جذور تتشابه مع الجزر
تحتوي الجذور على اسباراجين وكالسيوسين وفورمونونيتين واستراجلوكوزيدات وكوماتاكينين و ستيرولات.
بعد الدراسات السريرية التي تمت على جذور نبات الاستراجالس في الولايات المتحدة الأمريكية أدخل العقار في دستور الدواء الأمريكي العشبي American Herbal Pharmacopoeia
يستخدم على نطاق واسع
• عامل مناعى له قدرات متفرده فى عدة مجالات ( مضاد للاكسده – مضاد ميكروبى – مضاد طفيليات ) وتاتى هذه الهبات نتيجة تنشيط الجهاز المناعى ومنها الخلايا اللميفاويه و الخلايا الملتهمه و الخلايا المبطنه الداخليه مما ينعكس تنشيط الخلايا المنتجه لمادة السيتوكين مما يؤدى الى فى النهايات استهداف الميكروبات و التخلص منها
• زيادة القدرات الدفاعيه للجهاز المناعى وذلك بزيادة افراز الاجسام المضاده المناعيه مثل Ig A / Ig M / Ig E / Ig O / Ig G وهذه الاجسام المناعيه منها ما يتواد على الاغشيه المخاطيه و الاخرى المتخصصه للعدوى النوعيه
• التثبط الفيروسى يحدث من خلال تنشيط الخلايا الجذعيه dendritic cell و تنشيط خلايا نائمه naïve cell والتى تتطور الى خلايا بى و الخلايا القاتله و افراز الانترفيرون
• عامل عام مهم مضاد للالتهابات حيث يتكاتف تاثير استراجاليس مع مايسمى toll like receptors pathways و تمر بعدة مراحل مما يؤدى الى تقليل محفز الالتهاب و اثر ممتاز كمضاد للالتهاب
• تحسين البيئه الميكروبيه فى الامعاء حيث انها تساعد على البكتريا النافعه و تؤدى الى تكوين مستعمرات لها
• اثر فعال فى سيولة الدم فيمكن استخدامه فى حالات الاجهاد بانواعه
ان الدراسات و الابحاث العلميه اوضحت ان معدل اضافه من 4-8 ملجرام / كيلو وزن حى و محاولة احداث اصابه منعت الاصابه و حدث تحسن فى الصحه العامه
أثر فعال على إعادة تنشيط و زيادة نشاط الخلايا الكبديه
The role of Astragalus membranaceus as immunomodulator in poultry
Published online by Cambridge University Press: 18 December 2018
Astragalus membranaceus (AM) is a member of the family Leguminosae which has been widely used as immunomodulatory agent. Astragalus polysaccharides (APS) possess promising biological activities like immune enhancing, anti-oxidant, anti-viral, anti-microbial and anti-parasitic activities. Researchers have studied the immune enhancing activities of AM in birds and reported that APS and sulphated APS (4 or 8 mg/kg of body weight) showed immunomodulatory effects broiler chicks infected with lipopolysaccharide and modulated the resulting negative effects. AM powder supplementation in broiler feed at levels of 0, 100, 200 and 300 mg /kg diet increased the immune organs weight and IgG level and improved the liver and kidney functions and antioxidant status. Dietary APS (10 g/kg) promoted the growth rate and the histology of jejunum of offspring chickens. The addition of crude AM at 0.5% in laying hen feed for 21 days was able to improve the composition of faecal microorganisms. The following review describes the structure and chemical composition of AM and its immunomodulatory role in improving the health status of poultry and its mechanisms of action.
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